Post-Doctoral Fellow - Lab of Dr. Tyagi at Jefferson Health

Job Details

Expertise sought: Human iPSC-Derived Microglia, Brain Organoids,
Neuroinflammation, and HIV Research

Job Description

A highly motivated Postdoctoral Fellow is sought to join the laboratory investigating the molecular and cellular mechanisms underlying HIV persistence, neuroinflammation, accelerated aging, and neurodegeneration. The laboratory utilizes cutting-edge human induced pluripotent stem cell (iPSC)-derived microglia, cerebral organoids, and advanced genomic approaches to identify novel therapeutic targets and develop innovative interventions for HIV-associated and age-related neurological disorders. The successful candidates will participate in exciting multidisciplinary projects focused on understanding how HIV infection, chronic inflammation, and drugs of abuse alter brain function and contribute to neurocognitive impairment, neurovascular dysfunction, and accelerated aging.

Application Materials: Cover letter describing research interests and career goals; 2) Curriculum vitae (CV); 3) Names and contact information for three references; 4) Representative publications.

NOTE: Candidates with experience in human iPSC-derived microglia, brain organoids, neuroinflammation, HIV biology, single-cell genomics are particularly encouraged to apply.

Research experience (post-Doc Fellow) in the following areas:

• Human iPSC-derived microglia and other brain cells • Generation and characterization of cerebral and brain organoids

• HIV infection and persistence in the central nervous system

• Neuroinflammation and inflammasome signaling

• Aging and age-associated neurodegenerative mechanisms

• HIV infection and latency models

• CRISPR/Cas genome engineering

• Single-cell RNA sequencing (scRNA-seq)

• Other common Molecular and cellular biology techniques

Responsibilities (post-Doc Fellow):

• Have a great interest in research and learning

• Come everyday

• Design and conduct independent research projects

• Mentor students, junior and other laboratory personnel

• Analyze and interpret experimental data

• Prepare manuscripts • Present findings at scientific meetings

• Involved in reagent ordering, storage, and organization.

• Assist with data collection and laboratory organization, and maintain detailed laboratory records

• Provide a very brief daily report in the evening about the lab activity of the day and planning for the next day

Qualifications (post-Doc Fellow):

• Ph.D. in Neuroscience, Cell Biology, Molecular Biology, Immunology, Virology, Stem Cell Biology, Biomedical Sciences, or a related field. The candidate should have strong publication record demonstrating research productivity.

Work Shift

Workday Day (United States of America)

Worker Sub Type

Regular

Employee Entity

Thomas Jefferson University

Primary Location Address

1020 Locust Street, Philadelphia, Pennsylvania, United States of America

Nationally ranked, Jefferson, which is principally located in the greater Philadelphia region, Lehigh Valley and Northeastern Pennsylvania and southern New Jersey, is reimagining health care and higher education to create unparalleled value. Jefferson is more than 65,000 people strong, dedicated to providing the highest-quality, compassionate clinical care for patients; making our communities healthier and stronger; preparing tomorrow's professional leaders for 21st-century careers; and creating new knowledge through basic/programmatic, clinical and applied research. Thomas Jefferson University, home of Sidney Kimmel Medical College, Jefferson College of Nursing, and the Kanbar College of Design, Engineering and Commerce, dates back to 1824 and today comprises 10 colleges and three schools offering 200+ undergraduate and graduate programs to more than 8,300 students. Jefferson Health, nationally ranked as one of the top 15 not-for-profit health care systems in the country and the largest provider in the Philadelphia and Lehigh Valley areas, serves patients through millions of encounters each year at 32 hospitals campuses and more than 700 outpatient and urgent care locations throughout the region. Jefferson Health Plans is a not-for-profit managed health care organization providing a broad range of health coverage options in Pennsylvania and New Jersey for more than 35 years.

Jefferson is committed to providing equal educational and employment opportunities for all persons without regard to age, race, color, religion, creed, sexual orientation, gender, gender identity, marital status, pregnancy, national origin, ancestry, citizenship, military status, veteran status, handicap or disability or any other protected group or status.

Benefits

Jefferson offers a comprehensive package of benefits for full-time and part-time colleagues, including medical (including prescription), supplemental insurance, dental, vision, life and AD&D insurance, short- and long-term disability, flexible spending accounts, retirement plans, tuition assistance, as well as voluntary benefits, which provide colleagues with access to group rates on insurance and discounts. Colleagues have access to tuition discounts at Thomas Jefferson University after one year of full time service or two years of part time service. All colleagues, including those who work less than part-time (including per diem colleagues, adjunct faculty, and Jeff Temps), have access to medical (including prescription) insurance.

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